Bioengineering
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10. Introduction
to Bioengineering. (2)
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| Lecture, two hours; discussion, one hour; outside study, three hours.
Preparation: high school biology, chemistry, mathematics, physics. Introduction
to scientific and technological bases for established and emerging subfields of
bioengineering, including biosensors, bioinstrumentation, and biosignal
processing, biomechanics, biomaterials, tissue engineering, biotechnology,
biological imaging, biomedical optics and lasers, neuroengineering, and
biomolecular machines. Letter grading. |
19. Fiat Lux Freshman Seminars. (1)
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Seminar, one hour. Discussion of and critical thinking about topics of
current intellectual importance, taught by faculty members in their areas of
expertise and illuminating many paths of discovery at UCLA. P/NP
grading.
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100.
Bioengineering Fundamentals (4)
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Lecture, four hours; discussion, one hour; outside study, seven hours.
Enforced requisites: Mathematics 32A, Physics 1B. Fundamental basis for analysis
and design of biological and biomedical devices and systems. Classical and
statistical thermodynamic analysis of biological systems. Material, energy,
charge, and force balances. Introduction to network analysis. Letter
grading.
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C101. Introduction to Biomedical Engineering. (4)
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(Formerly numbered Biomedical Engineering C101.) Lecture, four hours;
discussion, one hour; outside study, seven hours. Enforced requisites:
Mathematics 33B, Physics 1B. Application of engineering principles for designing
and understanding delivery of therapeutics. Discussion of physics and
mathematics required for understanding colloidal stability. Analysis of concepts
related to both modeling and experimentation of endocytosis and intracellular
trafficking mechanisms. Analysis of diffusion of drugs, coupled with
computational and engineering mathematics approaches. Concurrently scheduled
with course C201. Letter grading.
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CM102. Basic Human Biology for Biomedical Engineers I. (4)
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(Formerly numbered Biomedical Engineering CM102.) (Same as Physiological
Science CM102.) Lecture, three hours; laboratory, two hours. Preparation: human
molecular biology, biochemistry, and cell biology. Not open for credit to
Physiological Science majors. Broad overview of basic biological activities and
organization of human body in system (organ/tissue) to system basis, with
particular emphasis on molecular basis. Modeling/simulation of functional aspect
of biological system included. Actual demonstration of biomedical instruments,
as well as visits to biomedical facilities. Concurrently scheduled with course
CM202. Letter grading.
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CM103. Basic Human Biology for Biomedical Engineers II. (4)
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(Formerly numbered Biomedical Engineering CM103.) (Same as Physiological
Science CM103.) Lecture, three hours; laboratory, two hours. Preparation: human
molecular biology, biochemistry, and cell biology. Not open for credit to
Physiological Science majors. Molecular-level understanding of human anatomy and
physiology in selected organ systems (digestive, skin, musculoskeletal,
endocrine, immune, urinary, reproductive). System-specific modeling/simulations
(immune regulation, wound healing, muscle mechanics and energetics, acid-base
balance, excretion). Functional basis of biomedical instrumentation (dialysis,
artificial skin, pathogen detectors, ultrasound, birth-control drug delivery).
Concurrently scheduled with course CM203. Letter grading.
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C104. Physical Chemistry of Biomacromolecules (4)
(Formerly numbered M104.) Lecture, three hours; discussion, two hours;
outside study, seven hours. Requisites: Chemistry 20A, 20B, 30A, Life Sciences
2, 3, 23L. To understand biological materials and design synthetic replacements,
it is imperative to understand their physical chemistry. Biomacromolecules such
as protein or DNA can be analyzed and characterized by applying fundamentals of
polymer physical chemistry. Investigation of polymer structure and conformation,
bulk and solution thermodynamics and phase behavior, polymer networks, and
viscoelasticity. Application of engineering principles to problems involving
biomacromolecules such as protein conformation, solvation of charged species,
and separation and characterization of biomacromolecules. Concurrently scheduled
with course C204. Letter grading.
C105. Biopolymer Chemistry and Bioconjugates (4)
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| (Formerly numbered M105.) Lecture, four hours; discussion, one hour;
outside study, seven hours. Enforced requisites: Chemistry 20A, 20B, 20L. Highly
recommended: one organic chemistry course. Bioconjugate chemistry is science of
coupling biomolecules for wide range of applications. Oligonucleotides may be
coupled to one surface in gene chip, or one protein may be coupled to one
polymer to enhance its stability in serum. Wide variety of bioconjugates are
used in delivery of pharmaceuticals, in sensors, in medial diagnostics, and in
tissue engineering. Basic concepts of chemical ligation, including choice and
design of conjugate linkers depending on type of biomolecule and desired
application, such as degradable versus nondegradable linkers. Presentation and
discussion of design and synthesis of synthetic bioconjugates for some sample
applications. Concurrently scheduled with course C205. Letter grading. |
C106. Topics in Biophysics, Channels, and Membranes (4)
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| (Formerly numbered M106.) Lecture, three hours; discussion, one hour;
outside study, eight hours. Enforced requisites: Chemistry 20B, Life Sciences 2,
3, 4, 23L, Mathematics 33B, Physics 1C, 4AL, 4BL. Coverage in depth of physical
processes associated with biological membranes and channel proteins, with
specific emphasis on electrophysiology. Basic physical principles governing
electrostatics in dielectric media, building on complexity to ultimately address
action potentials and signal propagation in nerves. Topics include Nernst/Planck
and Poisson/Boltzmann equations, Nernst potential, Donnan equilibrium, GHK
equations, energy barriers in ion channels, cable equation, action potentials,
Hodgkin/Huxley equations, impulse propagation, axon geometry and conduction,
dendritic integration. Concurrently scheduled with course C206. Letter grading. |
C107. Polymer Chemistry for Bioengineers (4)
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(Formerly numbered M107.) Lecture, four hours; discussion, one hour;
outside study, seven hours. Requisite: course C104 or C105. Fundamental concepts
of polymer synthesis, including step-growth, chain growth (ionic, radical, metal
catalyzed), and ring-opening, with focus on factors that can be used to control
chain length, chain length distribution, and chain-end functionality, chain
copolymerization, and stereochemistry in polymerizations. Presentation of
applications of use of different polymerization techniques. Concepts of
step-growth, chain-growth, ring-opening, and coordination polymerization, and
effects of synthesis route on polymer properties. Lectures include both theory
and practical issues demonstrated through examples. Concurrently scheduled with
course C207. Letter grading.
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110. Biotransport and Reaction Processes (4)
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Lecture, four hours; discussion, one hour; outside study, seven hours.
Enforced requisites: course 100, Mathematics 33B. Introduction to analysis of
fluid flow, heat transfer, mass transfer, binding events, and biochemical
reactions in systems of interest to bioengineers, including cells, tissues,
organs, human body, extracorporeal devices, tissue engineering systems, and
bioartificial organs. Introduction to pharmacokinetic analysis. Letter
grading.
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120. Biomedical Transducers (4)
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Lecture, four hours; discussion, one hour; outside study, seven hours.
Enforced requisites: Chemistry 30A, Electrical Engineering 1 or Physics 1C,
Electrical Engineering 100, Mathematics 32B. Principles of transduction, design
characteristics for different measurements, reliability and performance
characteristics, and data processing and recording. Emphasis on silicon-based
microfabricated and nanofabricated sensors. Novel materials, biocompatibility,
biostability. Safety of electronic interfaces. Actuator design and interfacing
control. Letter grading.
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C131. Nanopore Sensing (4)
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(Formerly numbered M131.) Lecture, four hours; discussion, one hour;
outside study, seven hours. Requisites: courses 100, 120, Life Sciences 2, 3,
23L, Physics 1A, 1B, 1C. Analysis of sensors based on measurements of
fluctuating ionic conductance through artificial or protein nanopores. Physics
of pore conductance. Applications to single molecule detection and DNA
sequencing. Review of current literature and technological applications. History
and instrumentation of resistive pulse sensing, theory and instrumentation of
electrical measurements in electrolytes, nanopore fabrication, ionic conductance
through pores and GHK equation, patch clamp and single channel measurements and
instrumentation, noise issues, protein engineering, molecular sensing, DNA
sequencing, membrane engineering, and future directions of field. Concurrently
scheduled with course C231. Letter grading.
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CM140. Introduction to Biomechanics (4)
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| (Formerly numbered Biomedical Engineering CM140.) (Same as Mechanical and
Aerospace Engineering CM140.) Lecture, four hours; discussion, two hours;
outside study, six hours. Enforced requisites: Mechanical and Aerospace
Engineering 101, 102, 156A. Introduction to mechanical functions of human body;
skeletal adaptations to optimize load transfer, mobility, and function. Dynamics
and kinematics. Fluid mechanics applications. Heat and mass transfer. Power
generation. Laboratory simulations and tests. Concurrently scheduled with course
CM240. Letter grading. |
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CM145. Molecular Biotechnology for Engineers. (4)
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(Formerly numbered Biomedical Engineering CM145.) (Same as Chemical
Engineering CM145.) Lecture, four hours; discussion, one hour; outside study,
eight hours. Selected topics in molecular biology that form foundation of
biotechnology and biomedical industry today. Topics include recombinant DNA
technology, molecular research tools, manipulation of gene expression, directed
mutagenesis and protein engineering, DNA-based diagnostics and DNA microarrays,
antibody and protein-based diagnostics, genomics and bioinformatics, isolation
of human genes, gene therapy, and tissue engineering. Concurrently scheduled
with course CM245. Letter grading.
C147. Applied Tissue Engineering: Clinical and Industrial Perspective (4)
(Formerly numbered Biomedical Engineering C147.) Lecture, three hours;
discussion, two hours; outside study, seven hours. Requisites: course CM102,
Chemistry 20A, 20B, 20L, Life Sciences 1 or 2. Overview of central topics of
tissue engineering, with focus on how to build artificial tissues into regulated
clinically viable products. Topics include biomaterials selection, cell source,
delivery methods, FDA approval processes, and physical/chemical and biological
testing. Case studies include skin and artificial skin, bone and cartilage,
blood vessels, neurotissue engineering, and liver, kidney, and other organs.
Clinical and industrial perspectives of tissue engineering products.
Manufacturing constraints, clinical limitations, and regulatory challenges in
design and development of tissue-engineering devices. Concurrently scheduled
with course C247. Letter grading. |
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CM150. Introduction to Micromachining and
Microelectromechanical Systems (MEMS) (4)
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(Formerly numbered Biomedical Engineering CM150.) (Same as Electrical
Engineering CM150 and Mechanical and Aerospace Engineering CM180.) Lecture, four
hours; discussion, one hour; outside study, seven hours. Requisites: Chemistry
20A, 20L, Physics 1A, 1B, 1C, 4AL, 4BL. Introduction to micromachining
technologies and microelectromechanical systems (MEMS). Methods of
micromachining and how these methods can be used to produce variety of MEMS,
including microstructures, microsensors, and microactuators. Students design
microfabrication processes capable of achieving desired MEMS device.
Concurrently scheduled with course CM250A. Letter grading.
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CM150L. Introduction to Micromachining and Microelectromechanical Systems Laboratory. (4)
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(Formerly numbered Biomedical Engineering CM150L.) (Same as Electrical
Engineering CM150L and Mechanical and Aerospace Engineering CM180L.) Lecture,
one hour; laboratory, four hours; outside study, one hour. Requisites: course
CM150, Chemistry 20A, 20L, Physics 1A, 1B, 1C, 4AL, 4BL. Hands-on introduction
to micromachining technologies and microelectromechanical systems (MEMS)
laboratory. Methods of micromachining and how these methods can be used to
produce variety of MEMS, including microstructures, microsensors, and
microactuators. Students go through process of fabricating MEMS device.
Concurrently scheduled with course CM250L. Letter grading.
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165EW. Bioengineering Ethics.
(4)
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| (Formerly numbered 165.) Lecture, four hours; discussion, three hours;
outside study, five hours. All professions have ethical rules that derive from
moral theory. Bioethics is well-established discipline that addresses ethical
problems about life, such as when do fertilized eggs become people? Should
ending of life ever be assisted? At what cost should it be maintained? Unlike
physicians, bioengineers do not make these decisions in practice. Engineering
ethics addresses ethical problems about producing devices from molecules to
bridges, such as when do concerns about risk outweigh concerns about cost? When
are weapons too dangerous to design? At what point does benefit of committing to
building devices outweigh need to wait for more scientific confirmation of their
effectiveness? Bioengineers must be aware of consequences of applying such
devices to all living systems. Emphasis on research and writing within
engineering environments. Satisfies engineering writing requirement. Letter
grading |
167L.
Bioengineering Laboratory. (4)
(Formerly numbered 182A.) Lecture, two hours; laboratory, six hours;
outside study, four hours. Enforced requisite: Chemistry 20L. Laboratory
experiments in fluorescence microscopy, bioconjugation, soft lithography, and
cell culture culminate in design of engineered surface for cell growth.
Introduction to techniques used in laboratories and their underlying physical or
chemical properties. Case studies connect laboratory techniques to current
biomedical engineering research and reinforce experimental design skills. Letter
grading.
C170. Laser-Tissue Interaction I. (4)
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(Formerly numbered Biomedical Engineering C170.) Lecture, three hours;
outside study, nine hours. Requisites: Electrical Engineering 172, 175, Life
Sciences 3, Physics 17. Corequisite: course C170L. Introduction to therapeutic
and diagnostic use of energy delivery devices in medical and dental
applications, with emphasis on understanding fundamental mechanisms underlying
various types of energy-tissue interactions. Concurrently scheduled with course
C270. Letter grading.
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C171. Laser-Tissue Interaction II: Biological Spectroscopy. (4)
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(Formerly numbered Biomedical Engineering C171.) Lecture, four hours;
outside study, eight hours. Requisite: course C170. Designed for physical
sciences, life sciences, and engineering majors. Introduction to optical
spectroscopy principles, design of spectroscopic measurement devices, optical
properties of tissues, and fluorescence spectroscopy biologic media.
Concurrently scheduled with course C271. Letter grading.
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C172 . Design of Minimally Invasive Surgical Tools. (4)
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(Formerly numbered M172.) Lecture, three hours; discussion, two hours;
outside study, seven hours. Requisites: Chemistry 30B, Life Sciences 2, 3, 23L,
Mathematics 32A. Introduction to design principles and engineering concepts used
in design and manufacture of tools for minimally invasive surgery. Coverage of
FDA regulatory policy and surgical procedures. Topics include optical devices,
endoscopes and laparoscopes, biopsy devices, laparoscopic tools, cardiovascular
and interventional radiology devices, orthopedic instrumentation, and
integration of devices with therapy. Examination of complex process of tool
design, fabrication, testing, and validation. Preparation of drawings and
consideration of development of new and novel devices. Concurrently scheduled
with course C272. Letter grading.
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176. Principles of
Biocompatibility. (4)
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Lecture, four hours; discussion, two hours; outside study, six hours.
Enforced requisites: course 100, Electrical Engineering 1 or Physics 1C,
Mathematics 33B. Biocompatibility at systemic, tissue, cellular, and molecular
levels. Biomechanical compatibility, stress/strain constitutive equations,
cellular and molecular response to mechanical signals, biochemical and cellular
compatibility, immune response. Letter grading.
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177A. Bioengineering Capstone Design I (4)
(Formerly numbered 182B.) Lecture, two hours; laboratory, six hours;
outside study, four hours. Enforced requisites: courses 167L, 176. Lectures,
seminars, and discussions on aspects of biomedical device and therapeutic
design, including topics such as need finding, intellectual property,
entrepreneurship, regulation, and project management. Working in teams, students
develop innovative solutions to address current problems in medicine and
biology. Sourcing and ordering of materials and supplies relevant to student
projects. Exploration of different experimental and computational methods.
Scientific presentation of progress. Letter grading.
177B. Bioengineering Capstone Design II (4)
(Formerly numbered 182C.) Lecture, two hours; laboratory, six hours;
outside study, four hours. Enforced requisite: course 177A. Lectures, seminars,
and discussions on aspects of biomedical device and therapeutic design,
including meetings with scientific/clinical advisers and guest lectures from
scientists in industry. Working in teams, students develop innovative solutions
to address current problems in medicine and biology. Students conduct directed
experiments and computational modeling, give oral presentations, write reports,
and participate in bioengineering design competition. Letter grading.
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CM178. Introduction to Biomaterials (4)
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(Formerly numbered Biomedical Engineering CM180.) (Same as Materials
Science CM180.) Lecture, three hours; discussion, two hours; outside study,
seven hours. Requisites: Chemistry 20A, 20B, and 20L, or Materials Science 104.
Engineering materials used in medicine and dentistry for repair and/or
restoration of damaged natural tissues. Topics include relationships between
material properties, suitability to task, surface chemistry, processing and
treatment methods, and biocompatibility. Concurrently scheduled with course
CM278. Letter grading.
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C179. Biomaterials-Tissue Interactions (4)
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(Formerly numbered Biomedical Engineering C181.) Lecture, three hours;
outside study, nine hours. Requisite: course CM178. In-depth exploration of host
cellular response to biomaterials: vascular response, interface, and clotting,
biocompatibility, animal models, inflammation, infection, extracellular matrix,
cell adhesion, and role of mechanical forces. Concurrently scheduled with course
C279. Letter grading.
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180. Systems
Integration in Biology, Engineering, and Medicine I (SIBEM I). (4)
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| Lecture, three hours; discussion, two hours; outside study, seven
hours. Requisites: courses 100, 110, 120, Life Sciences 3, Physics 4BL.
Corequisite: course 180L. Part I of two-part series. Molecular basis of normal
physiology and pathophysiology, and engineering design principles of
cardiovascular and pulmonary systems. Fundamental engineering principles of
selected medical therapeutic devices. Letter grading. |
180L. Systems Integration in Biology, Engineering, and Medicine II Laboratory (SIBEM I Laboratory). (3)
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Lecture, one hour; laboratory, four hours; clinical visits, three hours; outside study, one hour. Corequisite: course 180. Hands-on experimentation and clinical applications of selected medical therapeutic devices associated with cardiovascular and pulmonary disorders. Letter grading.
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181. Systems Integration in Biology, Engineering, and Medicine II (SIBEM II). (4)
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Lecture, three hours; discussion, two hours; outside study, seven hours. Requisite: course 180L. Corequisite: course 181L. Part II of two-part series. Molecular basis of normal physiology and pathophysiology of selected organ systems; engineering design principles of digestive and urinary systems. Fundamental engineering principles of selected medical therapeutic devices. Letter grading.
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181L. Systems Integration in Biology, Engineering, and Medicine II Laboratory (SIBEM II Laboratory). (3)
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Lecture, one hour; laboratory, four hours; clinical visits, three hours; outside study, one hour. Corequisite: course 181. Hands-on experimentation and clinical applications of molecular basis of normal physiology and pathophysiology of selected organ systems; engineering design principles of digestive and urinary systems. Letter grading.
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C183. Targeted Drug Delivery and Controlled Drug Release. (4)
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(Same as Biomedical Engineering CM183.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 20L. New therapeutics require comprehensive understanding of modern biology, physiology, biomaterials, and engineering. Targeted delivery of genes and drugs and their controlled release are important in treatment of challenging diseases and relevant to tissue engineering and regenerative medicine. Drug pharmacodynamics and clinical pharmacokinetics. Application of engineering principles (diffusion, transport, kinetics) to problems in drug formulation and delivery to establish rationale for design and development of novel drug delivery systems that can provide spatial and temporal control of drug release. Introduction to biomaterials with specialized structural and interfacial properties. Exploration of both chemistry of materials and physical presentation of devices and compounds used in delivery and release. Letter grading.
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C185. Introduction to Tissue Engineering. (4)
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Lecture, three hours; outside study, nine hours. Requisites: course CM102 or CM202, Chemistry 20A, 20B, 20L. Tissue engineering applies principles of biology and physical sciences with an engineering approach to regenerate tissues and organs. Guiding principles for proper selection of three basic components for tissue engineering: cells, scaffolds, and molecular signals. Concurrently scheduled with course C285. Letter grading.
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CM186. Computational Systems Biology: Modeling and Simulation of Biological Systems (5)
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(Formerly numbered CM186B.) (Same as Computational and Systems Biology M186 and Computer Science CM186.) Lecture, four hours; laboratory, three hours; outside study, eight hours. Corequisite: Electrical Engineering 102. Dynamic biosystems modeling and computer simulation methods for studying biological/biomedical processes and systems at multiple levels of organization. Control system, multicompartmental, predator-prey, pharmacokinetic (PK), pharmacodynamic (PD), and other structural modeling methods applied to life sciences problems at molecular, cellular (biochemical pathways/networks), organ, and organismic levels. Both theory- and data-driven modeling, with focus on translating biomodeling goals and data into mathematics models and implementing them for simulation and analysis. Basics of numerical simulation algorithms, with modeling software exercises in class and PC laboratory assignments. Concurrently scheduled with course CM286. Letter grading.
CM187. Thesis Research and Research Communication in Computational and Systems Biology (2 to 4)
(Formerly numbered CM186C.) (Same as Computational and Systems Biology M187 and Computer Science CM187.) Lecture, one hour; discussion, two hours; laboratory, one hour; outside study, eight hours. Requisite: course CM186. Closely directed, interactive, and real research experience in active quantitative systems biology research laboratory. Direction on how to focus on topics of current interest in scientific community, appropriate to student interests and capabilities. Critiques of oral presentations and written progress reports explain how to proceed with search for research results. Major emphasis on effective research reporting, both oral and written. Concurrently scheduled with course CM287. Letter grading.
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Chemistry and
Biochemistry
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20A. Chemical Structures.
(4)
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| Lecture, three hours; discussion, one hour. Preparation: high
school chemistry or equivalent background and three and one-half years of high
school mathematics. Recommended: high school physics. Enforced requisite:
successful completion of Chemistry Diagnostic Examination. First term of general
chemistry. Survey of chemical processes, quantum chemistry, atomic and molecular
structure and bonding, molecular spectroscopy. P/NP or letter grading. |
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20B. Chemical Energetics and Change.
(4)
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Lecture, three hours; discussion, one hour. Enforced requisites:
course 20A or 20AH, and Mathematics 31A, with grades of C- or better. Second
term of general chemistry. Intermolecular forces and organization, phase
behavior, chemical thermodynamics, solutions, equilibria, reaction rates and
laws. P/NP or letter grading.
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20L. General
Chemistry Laboratory I. (3)
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Lecture, one hour; laboratory, three hours. Enforced requisite:
course 20A with a grade of C- or better. Enforced corequisite: course 20B. Use
of the balance, volumetric techniques, volumetric and potentiometric analysis;
Beer's law, applications for environmental analysis and materials science. P/NP
or letter grading.
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30A. Chemical
Dynamics and Reactivity: Introduction to Organic Chemistry. (4)
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Lecture, three hours; discussion, one hour. Enforced requisite:
course 20B with a grade of C- or better. First term of organic chemistry.
Mechanisms of organic and inorganic reactions, including redox, elimination,
addition, substitution, and radical processes. P/NP or letter grading.
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30AL. General
Chemistry Laboratory II. (4)
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Lecture, one hour; laboratory, six hours. Enforced requisites:
courses 20B (or 20BH) and 20L, with grades of C- or better. Enforced
corequisite: course 30A or 30AH. Qualitative and quantitative analysis of
chemical reactions and compounds, kinetics, separations, and spectroscopy. P/NP
or letter grading.
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30B. Organic Chemistry:
Reactivity and Synthesis, Part I. (4)
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Lecture, three hours; discussion, one hour.
Enforced requisite: course 30A or 30AH, with a grade of C- or better. Second
term of organic chemistry. Synthesis, properties, and reactions of organic
functional groups, including alcohols, alkenes, alkynes, aromatic compounds,
aldehydes, ketones, carboxyl derivatives, and amines. P/NP or letter
grading.
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30BL. Organic Chemistry Laboratory
I. (3)
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Lecture, one hour; laboratory, four hours. Enforced requisites:
courses 30A (or 30AH) and 30AL, with grades of C- or better. Enforced
corequisite: course 30B. Basic experimental techniques in organic synthesis
(distillation, extraction, crystallization, and performing reactions) and
organic analytical chemistry (melting and boiling point, refractive index,
chromatography, IR, NMR, GC). Single and multistep synthesis of known organic
molecules on microscale level. P/NP or letter grading.
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153A.
Biochemistry: Introduction to Structure, Enzymes, and Metabolism.
(4)
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Lecture, four hours; discussion, one hour. Requisite: course 14D
or 30B with a grade of C- or better. Recommended: Life Sciences 2, 3. Structure
of proteins, carbohydrates, and lipids; enzyme catalysis and principles of
metabolism, including glycolysis, citric acid cycle, and oxidative
phosphorylation. Letter grading.
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