Speaker: Dr. Andrea Armani
Using light to measure the mechanical behavior of tissue
Understanding the mechanical behavior of biological materials is immensely complex due to the heterogeneity of the architecture at both the nano- and microscale. For example, in a tissue slice, cells are connected by the extracellular matrix (ECM). While it is clear that the ECM and the cells have different stiffness values, recent results show an inter-dependence between the two systems. However, it is not clear if the cells change in response to changes in ECM stiffness or vice versa. The nature of this dependence is of particular importance in tissue where the structure and mechanical properties directly determine the physiological behavior. Therefore, understanding the cause and effect has the potential to inform treatment; for example, understanding resistance to therapies, organ rejection, and disease progression. However, measuring the sample stiffness in unprocessed tissue is a particularly complex task. We have recently demonstrated a fully integrated polarimetric elastography instrument for characterizing the mechanical properties of visco-elastic materials, including tissue. This portable system shows promise for rapid testing and characterization of animal and human tissue samples, enabling numerous types of research investigations.
Date(s) - May 04, 2017
12:00 pm - 1:00 pm