Heather Maynard Phd

maynard

Associate Professor
Department of Chemistry and Biochemistry

Mol Sci Bldg 4234, 4230, 4221 (labs)
310-267-5162 | 310-206-1102, 310-825-8785, 310-825-7385, 310-825-8092 (labs) | 310-206-4038

Education

  • BS, University of North Carolina at Chapel Hill, 1992
  • MS, University of California, Santa Barbara, 1995
  • PhD, California Institute Technology, 2000
  • American Cancer Society Postdoctoral Fellow, Swiss Federal Institute of Technology (ETH) & University of Zurich (2000-02)

Honors and Awards

  • Fellow of the Royal Society of Chemistry, 2011
  • Kavli Frontiers Fellow, 2011
  • Walter Enz Memorial Lecturer, University of Kansas, 2008
  • Hanson-Dow Award for Excellence in Teaching, 2007
  • Hanson-Dow Award for Excellence in Teaching, 2007
  • NSF CAREER Award, 2007-2012
  • Alfred P. Research Fellowship, 2006-2008
  • Selected as an Outstanding Emerging Investigator in Materials Chemistry by Journal of Materials Chemistry, 2007
  • WCC ACS Lecturer, South Methodist University, 2006
  • Amgen New Faculty Award, 2004
  • Howard Reiss Career Development Chair, 2002-2007
  • American Cancer Society Postdoctoral Fellowship, 2000-2002
  • American Chemical Society Women’s Committee Travel Award, 1998
  • Dow Travel Fellowship Award, 1997
  • Bausch & Lomb Science Award for Excellence in Chemistry, 1987

Research Interests

The Maynard research group creates synthetic approaches to
both solution and surface bound biohybrids and explores the application of
these nanomaterials in medicine and biotechnology. There are three main
research thrusts within the group. (I) Well-defined protein and peptide polymer
conjugates are prepared by living/controlled polymerizations. These conjugates
are synthesized by polymerizing from proteins and amino acid-reactive
initiators and applied as capture agents for proteomics and for wound healing.
(II) Homo and block copolymers with reactive side chains are synthesized by
controlled radical polymerizations. Click chemistry is exploited to modify the
polymers for drug delivery. Inhibition of anthrax toxin and cancer are two of
the current targets of interest. (III) Polymer films for conjugation of
proteins to surfaces in specific orientation are prepared. Both micron and
nano-sized patterns of proteins have been fabricated for use as biomaterial
coatings.

 
 

Recent Papers

  1. Koldoziej C.M., Kim S.H., Broyer R.M., Saxer S.S., Decker C.G., Maynard H.D., “Combination of integrin-binding Peptide and growth factor promotes cell adhesion on electron-beam-fabricated patterns,” J Am Chem Soc. 2012 Jan 11;134(1):247-55. Epub 2011 Dec 22.
  2. Chang C.W., Nguyen T.H., Maynard H.D., “Thermoprecipitation of Glutathione S-Transferase by Glutathione-Poly(N-isopropylacrylamide) Prepared by RAFT Polymerization,” Macromol Rapid Commun. 2010 Oct 1;31(10):1691-5. Epub 2010 Aug 16.
  3. Heredia K.L., Tao L., Grover G.N., Maynard H.D., “Heterotelechelic Polymers for Capture and Release of Protein-Polymer Conjugates,” J Polym Sci A Polym Chem. 2010 Apr 1;1(2):168-70.
  4. Broyer R.M., Grover G.N., Maynard H.D., “Emerging synthetic approaches for protein-polymer conjugations,” Chem Commun (Camb). 2011 Feb 28;47(8):2212-26. Epub 2011 Jan 12.
  5. Christman K.L., Broyer R.M., Schopf E., Kolodziej C.M., Chen Y., Maynard H.D., “Protein nanopatterns by oxime bond formation,” Langmuir. 2011 Feb 15;27(4):1415-18. Epub 2010 Dec 30.
  6. Grover G.N., Maynard H.D., “Protein-polymer conjugates: synthetic approaches by controlled radical polymerizations and interesting applications,” Curr Opin Chem Biol. 2010 Dec;14(6):818-27. Epub 2010 Nov 10. Review.
  7. Alconcel S.N., Grover G.N., Matsumoto N.M., Maynard H.D., “Synthesis of Michael Acceptor Ionomers of Poly(4-Sulfonated Styrene-co-Poly(Ethylene Glycol) Methyl Ether Acrylate),” Aust J Chem. 2009 Nov 20;62(11):1496-1500.
  8. Mancini R.J., Li R.C., Tolstyka Z.P., Maynard H.D., “Synthesis of a photo-caged aminooxy alkane thiol,” Org Biomol Chem. 2009 Dec 7;7(23)”4954-9. Epub 2009 Oct 6.
  9. Tao L., Kaddis C.S., Loo R.R., Grover G.N., Loo J.A., Maynard H.D., “Synthesis of Maleimide-End Functionalized Star Polymers and Multimeric Protein-Polymer Conjugates,” Macromolecules. 2009 Nov 10;42(21):8028-8033.
  10. Grover G.N., Alconcel S.N., Matsumoto N.M., Maynard H.D., “Trapping of Thiol Terminated Acrylate Polymers with Divinyl Sulfone to Generate Well-Defined Semi-Telechelic Michael Acceptor Polymers,” Macromolecules. 2009 Oct 27;42(20):7657-63.