Michael Teitell M.D., Ph.D.

teitell

Professor
Department of Pathology and Laboratory Medicine
Department of Pediatrics
Division of Pediatric and Neonatal Pathology

310-206-6754 | 310-206-6821 (lab) | 310-267-0657 (fax)
 | Teitell Group Website

 

Education

  • BS, Biochemistry, University of California, Los Angeles, 1985
  • MS, Biochemistry, University of California, Los Angeles, 1985
  • PhD, Immunology, University of California, Los Angeles, 1991
  • MD, University of California, Los Angeles, 1993
  • Residency in Anatomic Pathology, Brigham & Women’s Hospital, 1995
  • Postdoctoral Fellowship, Harvard Medical School, Dr. Richard Blumberg, 1995
  • Residency in Clinical Pathology, University of California, San Francisco, 1997
  • Postdoctoral Fellowship, University of California, San Francisco, Dr. Joe Gray, 1997
  • Fellowship in Pediatric Pathology, Children’s Hospital Los Angeles, 1999
  • Clinical Instructorship, CHLA and UCLA, 1999

 

Awards and Positions

  • Lya and Harrison Endowed Chair in Pathology, 2012 – present
  • Elliot Osserman Award in Support of Cancer Research, 2011
  • Stohlman Scholar, Leukemia and Lymphoma Society, 2008
  • American Society of Clinical Investigators, 2004
  • Scholar Award, Leukemia and Lymphoma Society, 2003 – 2008
  • FOCIS/Millenium Pharmaceuticals Genomics Research Award, 2001
  • Lymphoma Research Foundation, Junior Faculty Award, 2001
  • Lymphoma Research Foundation of America Fellow, 1999
  • Chief, Division of Pediatric and Neonatal Pathology, Geffen School of Medicine
  • Director, Cancer Nanotechnology Program Area, Jonsson Cancer Center
  • Director, Tumor Immunology Training Program
  • Associate Director, UCLA-Caltech Medical Scientist Training Program
  • Co-Director, Broad Stem Cell Research Center Bioengineering Core
  • Faculty Member, California NanoSystems Institute
  • Faculty Member, Molecular Biology Institute
  • Faculty Athletics Representative, Intercollegiate Sports, UCLA & NCAA

Research Interests

Research in the Teitell lab began with studies on fundamental mechanisms of cancer formation and progression. This led to projects in stem and cancer cell metabolism and the collaborative development of new approaches in cell engineering and diagnostics. Currently active project areas in the group include:

  1. Mechanisms that control B cell differentiation into antibody-secreting plasma cells versus transformation into aggressive B cell leukemias and lymphomas in germinal centers
  1. Studies of a pathway for importing small non-coding RNAs into mitochondria to regulate cell respiration and energy production
  1. Metabolism and mitochondrial function in human pluripotent stem cells, which resembles metabolism in cancer cells
  1. Co-invention of (1) a photothermal nanoblade for delivering large cargo, such as mitochondria or intracellular pathogens, into mammalian cells and (2) a live cell interferometer, for dissecting cellular heterogeneity and profiling cell responses to environmental perturbations (e.g. therapeutics) in real-time

These distinct areas of study converge on the common goal of increased understanding, diagnosis and treatment of human malignancies in the context of changes that arise compared to normal development and function.

Recent Papers

 

    1. Wu, Y.-C., Wu, T.-H., Clemens, D.L., Lee, B.-Y., Wen, X., Horwitz, M.A., Teitell, M.A., and Chiou, P.-Y. Massively Parallel Delivery of Large-Sized Cargo into Mammalian Cells with Light Pulses. Nature Methods, 12(5): 439-444, 2015
    2. Teslaa, T and Teitell, M.A. Pluripotent Stem Cell Energy Metabolism: An Update. EMBO J, 34(2): 138-153, 2015
    3. Zangle, T.A. and Teitell, M.A. Live Cell Mass Profiling: An Emerging Approach in Quantitative Biophysics. Nature Methods, 11(12): 1221-1228, 2014
    4. Zangle, T.A., Chun, J., Zhang, J., Reed, J., and Teitell, M.A. Quantification of Biomass and Cell Motion in Human Pluripotent Stem Cell Colonies. Biophysical Journal, 105:593-601, 2013
    5. Dabir, D., Hasson, S.A., Setoguchi, K., Johnson, M.E., Wongkongkathep, P., Douglas, C.J., Zimmerman, J., Damoiseaux, R., Teitell, M.A., and Koehler, C.M. MitoBloCK-6: A Small Molecule Inhibitor of Redox-Regulated Protein Translocation in Mitochondria. Developmental Cell, 25:81-92, 2013
    6. Zhang, J., Nuebel, E., Daley, G.Q., Koehler, C.M., and Teitell, M.A. Metabolic Regulation in Pluripotent Stem Cells During Reprogramming and Self-Renewal. Cell Stem Cell, 11:589-595, 2012
    7. Zhang, J., Nuebel, E., Wisidagama, D.R.R., Setoguchi, K., Hong, J.S., Van Horn, C. M., Imam, S.S., Vergnes, L., Malone, C.S., Koehler, C.M., and Teitell, M.A. Measuring Energy Metabolism in Cultured Cells, Including Human Pluripotent Stem Cells and Differentiated Cells. Nature Protocols, 7:1068-1085, 2012
    8. Zhang, J., Khvorostov, I., Hong, J.S., Oktay, Y., Vergnes, L., Nuebel, E., Wahjudi, P.N., Setoguchi, K., Wang, G., Do, A., Jung, H.-J., McCaffery, J.M., Kurland, I.J., Reue, K., Lee, W.N.P., Koehler, C.M., and Teitell, M.A. UCP2 Regulates Energy Metabolism and Differentiation Potential of Human Pluripotent Stem Cells. EMBO Journal, 30:4860-4873, 2011
    9. Huang, Y., Park, Y., Wang-Zhu, Y., Larange, A., Arens, R., Bernardo, I., Olivares-Villagomez, D., Mendez-Fernandez, Y.V., Herndler-Brandstetter, D., Abraham, N., Grubeck-Loebenstein, B., Schoenberger, S.P., Van Kaer, L., Kronenberg, M., Teitell, M. A., and Cheroutre, H. Affinity-Based Selection of Mucosal CD8 Memory T Cells by an MHC Class I Molecule. Nature Immunology, 12:1086-1095, 2011
    10. Reed, J., Chun, J., Zangle, T.A., Kalim, S., Hong, J.S., Pefley, S.E., Zheng, X., Gimzewski, J.K., and Teitell, M.A. Rapid, Massively Parallel Single-Cell Drug Response Measurements Via Live Cell Interferometry. Biophysical Journal, 101:1025-1031, 2011
    11. French, C.T., Toesca, I.J., Wu, T.-H., Teslaa, T., Beaty, S.M., Wong, W., Liu, M.H., Schroeder, I.S., Chiou, P.-Y., Teitell, M.A., and Miller, J.F. Dissection of the Burkholderia Intracellular Lifecycle Using a Photothermal Nanoblade. Proceedings of the National Academy of Sciences, USA, 108: 12095-12100, 2011
    12. Wu, T.-H., TeSlaa, T., Kalim, S., French, C.T., Maghadam, S., Wall, R., Miller, J.F., Witte, O.N., Teitell, M.A., and Chiou, P.-Y. Photothermal Nanoblade for Large Cargo Delivery into Mammalian Cells. Analytical Chemistry, 83:1321-1327, 2011
    13. Sherman, M.H., Bassing, C.H., and Teitell, M.A. DNA Damage Response Regulates Cell Differentiation. Trends in Cell Biology, 21: 312-319, 2011
    14. Sherman, M.H., Kuraishy, A.I., Desphpande, C., Hong, J.S., Cacalano, N.A., Gatti, R.A., Manis, J.P., Damore, M.A., Pellegrini, M., and Teitell, M.A. AID-Induced Genotoxic Stress Promotes B Cell Differentiation in the Germinal Center via ATM and LKB1 Signaling. Molecular Cell, 39: 873-885, 2010
    15. Wang, G., Chen, H.-C., Oktay, Y., Zhang, J., Allen, E.L., Smith, G.M., Fan, K.C., Hong, J.S., French, S.W., McCaffery, J.M., Lightowlers, R.N., Morse III, H.C., Koehler, C.M., and Teitell, M.A. PNPASE Regulates RNA Import into Mitochondria. Cell, 142:456-467, 2010