Research in the Lee group focuses on the development of
biomimetic polymer systems for tissue regeneration and drug delivery
applications. His research interests are:
biomimetic scaffolds. Dr. Lee is developing a novel computer-designed,
biomimetic scaffolding system to maximize bone regeneration. This system
consists of three-dimensional polymer scaffolds with well-defined geometries on
the macro- and micro-scales created from a printing technique in conjunction
with biomimetic processing strategy to confer bone mineral-mimicking apatite
microenvironment and osteogenic signaling molecules.
release. Direct therapeutic applications of drug molecules require high doses
and repeated injections of protein drugs due to their rapid degradation in the
body. Dr. Lee’s research interests are in the development of
injectable/implantable systems for the delivery of growth factors in a
sustained, combinatorial, or sequential manner. He is currently applying these
systems to engineer a variety of tissue types, including bone, cartilage,
smooth muscle, and maxillofacial tissues.
Photopolymerizable hydrogel systems. Dr. Lee is developing injectable
formulations of cells and bioactive molecules using photopolymerization
techniques, which allow processing in situ at physiological conditions in a
minimally invasive manner. This system is currently being tested in vitro and
in animal models for the repair of cartilage defects.
- Park H., Choi B., Hu J., Lee M. “Injectable chitosan hyaluronic acid hydrogels for cartilage tissue engineering.” Acta Biomaterialia. 91(1):4779-86, 2013.
- Chang J., Liu F., Lee M., Wu B.M., Ting K., Zara J., Soo C., Hezaiman K.A., Zou W., Chen X., Mooney D., Wang C.Y. NF-kB inhibits osteogenic differentiation of mesenchymal stem cells by promoting b-catenin degradation.” Proceedings of the National Academy of Sciences. 110(23):9469-74, 2013.
- Park H., Choi B., Ng J., Fan J., Shafi S., Klokkevold P., Lee M. “Anionic Carbohydrate containing Chitosan Scaffolds for Bone Regeneration.” Carbohydrate Polymers. 97(2):587-96, 2013.
- Hu J., Hou Y., Park H., Choi B., Hou S., Chung A., Lee M. “Visible light crosslinkable chitosan hydrogels for tissue engineering.” Acta Biomaterialia. 8(5):1730-38, 2012.
- Hu J,. Hou Y., Park H., Lee M. “Beta tricalcium phophate particles as a controlled release carrier of osteogenic proteins for bone tissue engineering.” Journal of Biomedical Materials Research A. 100(7):1680-6, 2012.
- Levi B., Hyun J.S., Montoro D.T., Lo D., Hu S., Sun N., Nag D., Lee M., Grova M., Nelson E.R., Lee A., Connolly A., Wu J.C., Gurtner G.C., Wan D.C., Longaker M.T. “In Vivo Directed Differentiation of Pluripotent Stem Cells for Skeletal Regeneration.” Proceedings of the National Academy of Sciences. 109(5):20379-84, 2012.
- Siu R., Zara J., Hou Y., Li W., Kwak J., James A., Zhang Z., Ting K., Wu B.M., Soo C., Lee M. “Cartilage regeneration mediated by Nell-1 in a rabbit cartilage defect model.” Tissue Engineering. Part A, 18:252-61,2012.
- Hou Y., Hu J., Park H., Lee M. “Chitosan-based nanoparticles as a sustained protein release carrier for tissue engineering applications.” Journal of Biomedical Materials Research A. 100(4):939-47, 2012.
- Lee M., Wu B.M. “Recent Advances in 3D Printing of Tissue Engineering Scaffolds.” Methods in Molecular Biology. 868:257-67, 2012.
- Levi B., Nelson E., Li S., Hyun J., Jia F., Glotzbach J., James A.W., Wan D.C., Montoro D., Lee M., Huang M., Quarto N., Gurtner G., Wu J., Longaker M.T. “Non-Integrating Knockdown and Customized Scaffold Design Enhances Human Adipose Derive Stem Cells in Skeletal Repair.” Stem Cells. 29(12):2018-29, 2011.