Dr. Pouratian’s primary
neurosurgical interest is in surgeries that preserve and restore functional to
patients, including movement disorder surgeries, surgeries for psychiatric
conditions, and surgeries for peripheral nerve injuries and tumors. In order to
do these surgeries, Dr. Pouratian uses advanced neuroimaging and brain and
nerve mapping techniques, including functional MRI, cortical stimulation
mapping, electrocorticographic (ECoG) mapping, optical imaging of intrinsic
signals, and intraoperative EMG and nerve conduction studies.
Dr. Pouratian’s research focuses
on further developing these mapping tools in order to expand the surgical
indications and to develop new therapies for functional preservation and
restoration. He is particulary interested in studying brain mapping signals to
develop brain-computer interfaces to help patients with severe motor and
Pouratian areas of clinical expertise include:
- Movement Disorders
- Deep Brain Stimulation (Parkinson’s, Tremor, Dystonia,
- Intrathecal therapy (baclofen)
- Microvascular decompression for hemifacial spasm
- Selective dorsal rhizotomy
- Peripheral Nerve Disorders
- Brachial plexus injury and reconstruction
- Nerve tumors
- Nerve pain (including carpal tunnel and cubital tunnel
- Nerve stimulation
- Microvascular decompression for trigeminal pain
- Balloon compression for trigeminal neuralgia
- Deep Brain Stimulation for cluster headaches
- Occipital nerve stimulation for occipital neuralgia
- Trigeminal stimulation for atypical facial pain
- Brain metastases
- Pituitary tumors
- Trigeminal neuralgia
- Spieler W., Arnold C., Lu J., Taira R.K., Pouratian N., “Natural language processing with dynamic classification improves P300 speller accuracy and bit rate,” J Neural Eng. 2011 Dec 12; 9(1):016004. (Epub ahead of print)
- Chou A.P., Lalezari S., Fong B.M., Dye J., Pham T., Vinters H.V., Pouratian N., “Post-transplantation primary central nervous system lymphoma: A case report and review of the literature,” Surg Neurol Int. 2011;2:130. Epub 2011 Sep 27.
- Pouratian N., Zheng Z., Bari A.A., Behnke E., Elias W.J., Desalles A.A., “Multi-institutional evaluation of deep brain stimulation targeting using probabilistic connectivity-based thalamic segmentation,” J Neurosurg. 2011 Nov;115(5):995-1004. Epub 2011 Aug 19.
- Pouratian N., “The brain and computer: The neurosurgical interface,” Surg Neurol Int. 2011;2:79. Epub 2011 Jun 15.
- Pouratian N., Reames D.L., Frysinger R., Elias W.J., “Comprehensive analysis of risk factors for seizures after deep brain stimulation surgery. Clinical article,” J Neurosurg. 2011 Aug;115(2):310-5. Epub 2011 May 6.
- Sedrak M., Gorgulho A., Bari A., Behnke E., Frew A., Gevorkyan I., Pouratian N., DeSalles A., “Diffusion tensor imaging (DTI) and colored fractional anisotropy (FA) mapping of the subthalamic nucleus (STN) and the globus pallidus interna (GPi),” Acta Neurochir (Wien). 2010 Dec;152(12):2079-84. Epub 2010 Oct 3.
- Pouratian N., Schiff D., “Management of low-grade glioma,” Curr Neurol Neurosci Rep. 2010 May;10(3):224-31. Review.
- Lee D.J., Pouratian N., Bookheimer S.Y., Martin N.A., “Factors predicting language lateralization in patients with perisylvian vascular malformations. Clinical article,” J Neurosurg. 2010 Oct;113(4):723-30.
- Pouratian N., Bookheimer S.Y. “The reliability of neuroanatomy as a predictor of eloquence: a review,” Neurosurg Focus. 2010 Feb;28(2):E3. Review.
- Guiou M., Sheth S., Nemoto M., Walker M., Pouratian N., Ba A., Toga A.W., “Cortical spreading depression produces long-term disruption of activity-related changes in cerebral blood volume and neurovascular coupling,” J Biomed Opt. 2005 Jan-Feb;10(1):11004.