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Dean Ho, Ph.D.

Dean Ho   Co-Director
  The Jane and Jerry Weintraub Center for Reconstructive Biotechnology
  UCLA School of Dentistry
  Professor
  Division of Oral Biology
  Division of Advanced Prosthodontics
  UCLA School of Dentistry
  
  CHS B3-068A
  
  dean.ho@ucla.edu | www.n-base.org

 

Education
  • B.S., Physiological Sciences, University of California, Los Angeles, December 2001
  • M.S., Biomedical Engineering, University of California, Los Angeles, June 2003
  • Ph.D., Biomedical Engineering, University of California, Los Angeles, January 2005
 
Awards and Recognitions
  • Society for Laboratory Automation and Screening (SLAS) Endowed Fellowship, 2012
  • Finalist, ICYRAM-IUMRS Young Researcher Award, 2012
  • National Academy of Engineering Frontiers of Engineering Symposium, 2010
  • Wallace H. Coulter Foundation Phase II Translational Research Award, 2010
  • Editor-in-Chief, Journal of Laboratory Automation, 2009
  • Society for Manufacturing Engineering John G. Bollinger Outstanding Young Manufacturing Engineer Award, 2009
  • National Science Foundation CAREER Award, 2009
  • Distinguished Young Alumnus Award - UCLA School of Engineering and Applied Science, 2008
  • V Foundation Scholar, V Foundation for Cancer Researcher, 2007
 
Research Contributions
  • Nanodiamond Hydrogel-Based Drug Delivery System
    As the world's first such system, it could potentially utilized with any drug to maximize benefits and minimize toxic effects. Comprehensive animal model studies show unaffected liver function and unaffected animal survival.  This discovery has been featured on CNN, Popular Science, United Press International, NSTI, Nanotechweb, and others.
  • Nanodiamond-Embedded Patch Device as a Localized Drug Delivery Implantable Microfilm
    This device is visually similar to "plastic wrap" embedded with slow slow release nanodiamonds. Due to the drug capacity of the nanodiamonds, the device can be small. Studies are currently being conducted with it in cardiovascular anti-inflammation, local chemotherapy, wound healing, and pain management. This has been featured on Reuters, Yahoo News, MSNBC, CNBC, Scientific American, and more.
  • Nanocloak Film Technology for Non-Invasive Localized Drug Delivery
    The technology is not only 10000 times thinner, but shows better efficacy than existing drug-delivery technology has been demonstrated in vivo with no toxicity observed. 

Recent Papers
  1. L. Moore, M. Gatica, E. Chow, and D. Ho*, Diamond-Based Nanomedicine: Enhanced Drug Delivery and Imaging, Disruptive Science and Technology, 1(1), 54-61, 2012.
  2. H.B. Man, R. Lam, M. Chen, E. Osawa, and D. Ho*, Nanodiamond-Therapeutic Complexes Embedded within Poly (Ethylene Glycol) Diacrylate Hydrogels Mediate Sequential Drug Elution, accepted, 2012. (Invited Paper from Hasselt Diamond Workshop).
  3. E. K. Chow, X.-Q. Zhang, M. Chen, R. Lam, E. Robinson, H. Huang, D. Schaffer, E. Osawa, A. Goga, and D. Ho*, Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment. Science Translational Medicine 3, 73ra21 (2011). COVER ARTICLE, featured on NPR homepage, Science, Nature, Agence France Presse, Yahoo News, Voice of America, C&E news.
  4. V. Mochalin, O. Shenderova, D. Ho, Y. Gogotsi, “The Properties and Applications of Nanodiamonds,” Nature Nanotechnology, 7, 11-23, 2011.
  5. X. Zhang^, X. Xu^, R. Lam, D. Giljohann, D. Ho*, and C. Mirkin*, “A Strategy for Increasing Drug Solubility and Efficacy Through Covalent Attachment to Polyvalent DNA-Nanoparticle Conjugates,” ACS Nano, DOI: 10.1021/nn201446c, 2011.(*Co-corresponding, ^ Co-first author)
  6. Xue-Qing Zhang, Robert Lam, Xiaoyang Xu, Edward K. Chow, Ho-Joong Kim and Dean Ho*, Multimodal Nanodiamond Drug Delivery Carriers for Selective Targeting, Imaging and Enhanced Chemotherapeutic Efficacy, Advanced Materials (To be featured in Materials Views), DOI: 10.1002/adma.201102263, 2011.
  7. A. Smith, E. Robinson, X. Zhang, E. Chow, E. Osawa, and D. Ho* “Triggered Release of Therapeutic Antibodies from Nanodiamond Complexes,” Nanoscale, 3, 2844-2848, DOI: 10.1039/C1NR10278H, 2011.
  8. M. Chen, X. Zhang, H. Man, R. Lam, E. Chow, and D. Ho* “Nanodiamond Vectors Functionalized with Polyethylenimine for siRNA Delivery” J. Phys. Chem.-L, 1 (21), pp 3167–3171, 2010.
  9. A. Adnan, R. Lam, H. Chen, J. Lee, D. Schaffer, A. Barnard, G. Schatz, D. Ho, and W. K. Liu, Atomistic Simulation and Measurement of pH Dependent Cancer Therapeutic Interactions with Nanodiamond Carrier, Mol. Pharm., 8 (2), pp 368–374, 2010.5
  10. L. Manus, D.J. Mastarone, E.A. Waters, X.-Q. Zhang, E.A. Schultz-Sikma, D. Ho, and T.J. Meade, Gd(III)-nanodiamond conjugates for MRI contrast enhancement,” Nano Letters, 10(2), p.484-489, 2010, Demonstrates among the highest nonviral per-Gd(III) relaxivity values ever reported.
 
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