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Dino Di Carlo, Ph.D.

dicarlopic Associate Professor
Department of Bioengineering

5121E Engineering V
310-983-3235
310-794-5956 fax
dicarlo@seas.ucla.edu | Di Carlo Group Website

Education

  • B.S., University of California, Berkeley, 2002
  • Ph.D., University of California, Berkeley and San Francisco, 2006
  • Postdoctoral Training with Professor Mehmet Toner, Harvard Medical School, Massachusetts General Hospital, Center for Engineering in Medicine, 2006-2008

Awards and Recognitions

  • NSF CAREER Award, 2012
  • ONR Young Investigator Award, 2012
  • Packard Fellow, 2011
  • DARPA Young Faculty Award, 2011
  • NIH Director's New Innovator Award, 2010
  • Coulter Translational Research Award, 2010
  • Postdoctoral Fellowship, American Cancer Society, 2007 - 2009

  • Best Poster Award (for work on large scale single cell analysis in microfluidics), Micro Total Analysis Systems Conference, Boston, 2005

  • Whitaker Foundation Graduate Fellowship, 2002 - 2006

  • MESA Fellow, Sandia National Laboratories, 2002 - 2003

  • Bioengineering Department Citation (one award given annually), 2001

Research Interests


We are exploiting unique physics, microenvironment control, and the potential for automation associated with miniaturized systems for applications in basic biology, medical diagnostics, and cellular engineering. Current research is focused on:

(i) Quantitative cell biology and mechanics of cancer metastasis. Microfluidic methods to control the surface chemistry, mechanical, and soluble environment are well suited to address questions associated with cell migration and movement. We are particularly interested in the process of cancer metastasis and intravasation.

(ii) Nonlinear microfluidics. Nonlinear fluid dynamic effects are usually not considered in microfluidic systems but may provide simple methods to manipulate and sort rare populations of cells at high-throughputs. We are studying the physical basis of inertial migration of particles and engineering novel portable and robust diagnostic and analysis systems using this phenomenon for applications in the developed and developing world.

(iii) Microfluidic directed cellular evolution. Microfluidic technologies may offer advantages in creating new useful selection criteria for cellular evolution. Besides gaining an understanding of dominant molecular pathways in controlling these behaviors, the resultant evolved cell populations and genetic modifications may be useful for therapeutic applications.

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 Recent Papers

  1. Mach AJ, Adeyiga O, Di Carlo D. Review: Microfluidic sample preparation for diagnostic cytopathology. Lab on a Chip (2013). doi:10.1039/C2LC41104K. 
  2. Chung AJ, Gossett DR, Di Carlo D. Three dimensional, sheathless, and high-throughput microparticle inertial focusing through geometry-induced secondary flows. Small (2012). doi:10.1002/smll.201202413.
  3. Tseng, P, Judy JW, Di Carlo D. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Nature Methods (2012). doi:10.1038/nmeth.2210. 
  4. Murray C, McCoul D, Sollier E, Ruggiero T, Niu X, Pei Q, Di Carlo D. Electro-adaptive microfluidics for active tuning of channel geometry using polymer actuators. Microfluidics and Nanofluidics (2012). doi:10.1007/s10404-012-1055-y. 
  5. Hur SC, Brinckerhoff TZ, Walthers CM, Dunn JCY, Di Carlo D. Label-free enrichment of adrenal cortical progenitor cells using intertial microfluidics. PLoS ONE (2012) 7(10): e46550. doi:10.1371/journal.pone.0046550. 
  6. Masaeli M, Sollier E, Amini H, Mao W, Camacho K, Doshi N, Mitragotri, S, Alexeev A, Di Carlo D. Continuous inertial focusing and separation of particles by shape. Physical Review X (2012) 2(3): 031017. doi:10.1103/PhysRevX.2.071017. 
  7. Weaver WM, Milisavljevic V, Miller JF, Di Carlo D. Fluid flow induces biofilm formation in Staphylococcus epidermidis polysaccharide intracellular adhesin-positive clinical isolates. Applied and Environmental Microbiology (2012) 78(16): 5890-5896. doi:10.1128/AEM.01139-12. 
  8. Amini H, Sollier E, Weaver WM, Di Carlo D. Intrinsic particle-induced lateral transport in microchannels. PNAS (2012) doi:10.1073/pnas.1207550109. 
  9. Gossett DR, Tse HTK, Dudani JS, Goda K, Woods TA, Graves SW, Di Carlo D. Inertial manipulation and transfer of microparticles across laminar fluid streams. Small (2012) doi:10.1002/smll.201200588.
  10. Goda K, Ayazi A, Gossett DR, Sadasivam J, Lonappan CK, Sollier E, Fard AM, Hur SC, Adam J, Murray C, Wang C, Brackbill N, Di Carlo D, Jalali B. High-throughput single-microparticle imaging flow analyzer. PNAS (2012) doi:10.1073/pnas.1204718109.

 Courses

 

  • BE 167L Bioengineering Lab
  • BE 177A Bioengineering Capstone Design I
  • BE 177B Bioengineering Capstone Design II
  • BE 155/255 Fluid-particle Fluid-structure Interactions in Microflows

 

 

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