Dr. Toga is interested in the development of
new algorithms and the computer science aspects important to neuroimaging. New
visualization techniques and statistical measurement are employed in the study
of morphometric variability in humans, subhuman primates and rodents.
His laboratory (Laboratory of
Neuro Imaging) has been working on the creation of three dimensional digital
neuroanatomic and functional neuroanatomic atlases for stereotactic
localization and multisubject comparison. Specific programs include the development
of local deformation techniques to equate brain data sets from different
modalities and different subjects and the development of electronic data bases
for the archival, interaction and distribution of brain data.
goal of the Laboratory of Neuro Imaging (LONI) is to improve the understanding
of the brain in health and disease. LONI develops novel strategies to
investigate brain structure and function in their full multidimensional
complexity. There is a rapidly growing need for brain models comprehensive
enough to represent brain structure and function as they change across time, in
large populations, in different disease states, across imaging modalities,
across age and gender, and even across species. A major focus of our research
is to develop 4D brain models that track and analyze complex patterns of
dynamically changing brain structure in development and disease, expanding
investigations of brain structure-function relationships to four dimensions.
- Yang Y., Nuechterlein K.H., Phillips O.R., Gutman B., Kurth F., Dinov I., Thompson P.M., Asarnow R.F., Toga A.W., Narr K.L., "Disease and genetic contributions toward local tissue volume disturbances in schizophrenia: A tensor-based morphometry study," Hum Brain Mapp. 2011 Aug 30. (Epub ahead of print)
- Jahanshad N., Kohannim O., Hibar D.P., Stein J.L., McMahon K.L. de Zubicaray G.I., Medland S.E., Montgomery G.W., Whitfield J.B., Martin N.G., Wright M.J., Toga A.W.< Thompson P.M., "Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene," Proc Natl Acad Sci U S A. 2012 Jan 9. (Epub ahead of print)
- Toga A.W., Dinvo I.D., Thompson P.M., Woods R.P., Van Horn J.D., Shattluck D.W., Parker D.S., "The Center for Computational Biology: resources, achievements, and challenges," J Am Med Inform Assoc. 2011 Nov 10. (Epub ahead of print)
- Hua X., Thompson P.M., Leow A.D., Madsen S.K., Caplan R., Alger J.R., O'Neill J., Joshi K., Smalley S.L., Toga A.W., Levitt J.G., "Brain growth rate abnormalities visualized in adolescents with autism," Hum Brain Mapp. 2011 Oct 20. (Epub ahead of print)
- Shi Y., Lai R., Gill R., Pelletier D., Mohr D., Sicotte N., Toga A.W., "Conformal metric optimization on surface (CMOS) for deformation and mapping in Laplace-Beltrami embedding space," Med Image Comput Comput Assist Interv. 2011;14(Pt 20:327-34.
- Dinov I.D., Torri F., Maciardi F., Petrosyan P., Liu Z., Zamanyan A., Eggert P., Pierce J., Genco A., Knowles J.A., Clark A.P., Van Horn J.D., Ames J., Kesselman C., Toga A.W., "Applications of the pipeline environment for visual informatics and genomics computations," BMC Bionformatics. 2011 Jul 26;12:304.
- Irimia A., Chambers M.C., Alger J.R., Filippou M., Prastawa M.W., Wang B., Hovda D.A., Gerig G., Toga A.W., Kikinis R., Vepsa P.M., Van Horn J.D., "Comparison of acute and chronic traumatic brain injury using semi-automatic multimodal segmentation of MR volumes," J Neurotrauma. 2011 Nov;28(11):2287-306. Epub 2011 Sep 21.
- Shi Y., Lai R., Toga A.W., "CoRPORATE: cortical reconstruction by pruning outliers with Reeb analysis and topology-preserving evolution," Inf Process Med Imaging. 2011;22:233-44.
- Joshi S.H., Bowman I., Toga A.W., Van Horn J.D., "BRAIN PATTERN ANALYSIS OF CORTICAL VALUED DISTRIBUTIONS," Proc IEEE Int Symp Biomed Imaging. 2011 Mar 30:1117-1120.
- Biag J., Huang Y., Gou L., Hinitryan H., Askarinam A., Hahn J.D,. Toga A.W., Dong H.W., "Cyto- and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: a study of immunostaining and multiple fluorescent tract tracing," J Comp Neurol. 2012 Jan 1;520(1):6-33.