Rajesh Kumar Ph.d

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Associate Professor In-Residence
Department of Anesthesiology

56-132 CHS
10833 Le Conte Ave

310-206-1679
rkumar@mednet.ucla.edu

 

Education

  • Ph.D., Sanjay Gandhi Postgraduate Institute of Medical Sciences

Research Interests

Dr. Kumar’s laboratory uses magnetic resonance spectroscopy
(MRS) and various MRI procedures, including high-resolution T1-weighted
imaging, T2-relaxometry, magnetization transfer imaging, diffusional kurtosis
imaging, diffusion tensor imaging, arterial spin labeling, and functional
magnetic resonance imaging to assist in the localization of abnormal brain
regions and assess neural activity in patients with OSA and HF. Research has
demonstrated that HF patients show brain injury in autonomic, mood, and
cognitive regulatory areas. The research team has also differentiated different
types of white matter injury (axonal or myelin injury), and showed that HF
subjects exhibit more neural damage than OSA patients, particularly in brain
areas that serve memory and mood functions. Dr. Kumar’s lab seeks to determine
the onset of the neural damage in HF and OSA, the specific cardiovascular or
breathing effects that the damage could exert, and the extent of progression as
the syndrome continues. These findings could lead to preventative measures
before the severe consequences, such as hypertension, stroke, and daytime
hypersomnia in OSA patients, and autonomic, mood and cognitive
deficits in HF patients. This research will help identify the problems earlier,
leading to earlier treatment, and give us a greater understanding of the causes
of HF and OSA.

Recent Papers

  • Serber Stacy L, Rinsky Brenda, Kumar
    Rajesh, Macey Paul M, Fonarow Gregg C, Harper Ronald M Cerebral blood flow
    velocity and vasomotor reactivity during autonomic challenges in heart failure.
    Nursing research. 2014; 63(3): 194-202.
  • Yadav Santosh K, Kumar Rajesh, Macey
    Paul M, Woo Mary A, Yan-Go Frisca L, Harper Ronald M Insular cortex metabolite
    changes in obstructive sleep apnea. Sleep. 2014; 37(5): 951-8.
  • Harper Ronald M, Kumar Rajesh, Macey
    Paul M, Woo Mary A, Ogren Jennifer A Affective brain areas and sleep-disordered
    breathing. Progress in brain research. 2014; 209(3): 275-93.
  • Kumar Rajesh, Farahvar Salar, Ogren
    Jennifer A, Macey Paul M, Thompson Paul M, Woo Mary A, Yan-Go Frisca L, Harper
    Ronald M Brain putamen volume changes in newly-diagnosed patients with
    obstructive sleep apnea. NeuroImage. Clinical. 2014; 4(3): 383-91.
  • Richardson Heidi L, Macey Paul M, Kumar
    Rajesh, Valladares Edwin M, Woo Mary A, Harper Ronald M Neural and
    physiological responses to a cold pressor challenge in healthy adolescents. Journal of neuroscience research. 2013; 91(12): 1618-27.
  • Macey Paul M, Kumar Rajesh, Woo Mary A,
    Yan-Go Frisca L, Harper Ronald M Heart rate responses to autonomic challenges
    in obstructive sleep apnea. PloS one. 2013; 8(10): e76631.
  • Yadav Santosh K, Kumar Rajesh, Macey
    Paul M, Richardson Heidi L, Wang Danny J J, Woo Mary A, Harper Ronald M
    Regional cerebral blood flow alterations in obstructive sleep apnea. Neuroscience letters. 2013; 555(12): 159-64.
  • Harper Ronald M, Kumar Rajesh, Ogren
    Jennifer A, Macey Paul M Sleep-disordered breathing: effects on brain structure
    and function. Respiratory physiology &
    neurobiology
    .
    2013; 188(3): 383-91.
  • Kumar Rajesh, Harper Ronald M Response.
    Journal of magnetic
    resonance imaging : JMRI
    .
    2013; 38(2): 506-7.
  • Kumar Rajesh, Chavez Alexa S, Macey
    Paul M, Woo Mary A, Harper Ronald M Brain axial and radial diffusivity changes
    with age and gender in healthy adults. Brain research. 2013; 1512(2): 22-36.
  • Pan Alan, Kumar Rajesh, Macey Paul M,
    Fonarow Gregg C, Harper Ronald M, Woo Mary A Visual assessment of brain
    magnetic resonance imaging detects injury to cognitive regulatory sites in
    patients with heart failure. Journal of cardiac failure. 2013; 19(2): 94-100.
  • Ogren Jennifer A, Macey Paul M, Kumar
    Rajesh, Fonarow Gregg C, Hamilton Michele A, Harper Ronald M, Woo Mary A
    Impaired cerebellar and limbic responses to the valsalva maneuver in heart
    failure. Cerebellum (London, England). 2012; 11(4): 931-8.
  • Macey Paul M, Kumar Rajesh, Yan-Go
    Frisca L, Woo Mary A, Harper Ronald M Sex differences in white matter
    alterations accompanying obstructive sleep apnea. Sleep. 2012; 35(12): 1603-13.
  • Kumar Rajesh, Chavez Alexa S, Macey
    Paul M, Woo Mary A, Yan-Go Frisca L, Harper Ronald M Altered global and
    regional brain mean diffusivity in patients with obstructive sleep apnea. Journal of neuroscience research. 2012; 90(10): 2043-52.
  • Harper Ronald M, Kumar Rajesh, Macey
    Paul M, Ogren Jennifer A, Richardson Heidi L Functional neuroanatomy and
    sleep-disordered breathing: implications for autonomic regulation. Anatomical record (Hoboken, N.J. : 2007). 2012; 295(9): 1385-95.
  • Macey Paul M, Moiyadi Ammar S, Kumar
    Rajesh, Woo Mary A, Harper Ronald M Decreased cortical thickness in central
    hypoventilation syndrome. Cerebral cortex (New York, N.Y. : 1991). 2012; 22(8): 1728-37.
  • Kumar Rajesh, Woo Marlyn S, Macey Paul
    M, Woo Mary A, Harper Ronald M Progressive gray matter changes in patients with
    congenital central hypoventilation syndrome. Pediatric research. 2012; 71(6): 701-6.
  • Macey Paul M, Wu Paula, Kumar Rajesh,
    Ogren Jennifer A, Richardson Heidi L, Woo Mary A, Harper Ronald M Differential
    responses of the insular cortex gyri to autonomic challenges. Autonomic neuroscience : basic & clinical. 2012; 168(1-2): 72-81.
  • Kumar Rajesh, Nguyen Haidang D, Macey
    Paul M, Woo Mary A, Harper Ronald M Regional brain axial and radial diffusivity
    changes during development. Journal of neuroscience research. 2012; 90(2): 346-55.
  • Kumar Rajesh, Woo Mary A, Macey Paul M,
    Fonarow Gregg C, Hamilton Michele A, Harper Ronald M Brain axonal and myelin
    evaluation in heart failure. Journal of the neurological sciences. 2011; 307(1-2): 106-13.
  • Kumar Rajesh, Nguyen Haidang D, Ogren
    Jennifer A, Macey Paul M, Thompson Paul M, Fonarow Gregg C, Hamilton Michele A,
    Harper Ronald M, Woo Mary A Global and regional putamen volume loss in patients
    with heart failure. European journal of heart
    failure
    . 2011; 13(6): 651-5.
  • Kumar R, Macey P M, Woo M A, Harper R M
    Selectively diminished corpus callosum fibers in congenital central
    hypoventilation syndrome. Neuroscience. 2011; 178(6): 261-9.
  • Kumar Rajesh, Delshad Sean, Macey Paul
    M, Woo Mary A, Harper Ronald M Development of T2-relaxation values in regional
    brain sites during adolescence. Magnetic resonance imaging. 2011; 29(2): 185-93.
  • Kumar Rajesh, Macey Paul M, Woo Mary A,
    Harper Ronald M Rostral brain axonal injury in congenital central
    hypoventilation syndrome. Journal of neuroscience research. 2010; 88(10): 2146-54.
  • Singhal Aparna, Nagarajan Rajakumar,
    Hinkin Charles H, Kumar Rajesh, Sayre James, Elderkin-Thompson Virginia, Huda
    Amir, Gupta Rakesh K, Han Steven-Huy, Thomas M Albert Two-dimensional MR
    spectroscopy of minimal hepatic encephalopathy and neuropsychological
    correlates in vivo. Journal of magnetic
    resonance imaging : JMRI
    .
    2010; 32(1): 35-43.
  • Ogren J A, Macey P M, Kumar R, Woo M A,
    Harper R M Central autonomic regulation in congenital central hypoventilation
    syndrome. Neuroscience. 2010; 167(4): 1249-56.
  • Macey Paul M, Kumar Rajesh, Ogren
    Jennifer A, Woo Mary A, Harper Ronald M Images in sleep medicine. Altered
    cerebral blood flow in a patient with congenital central hypoventilation
    syndrome. Sleep medicine. 2010; 11(6): 589-90.
  • Macey Paul M, Woo Mary A, Kumar Rajesh,
    Cross Rebecca L, Harper Ronald M Relationship between obstructive sleep apnea
    severity and sleep, depression and anxiety symptoms in newly-diagnosed
    patients. PloS one. 2010; 5(4): e10211.
  • Kumar Rajesh, Nguyen Haidang D, Macey
    Paul M, Woo Mary A, Harper Ronald M Dilated basilar arteries in patients with
    congenital central hypoventilation syndrome. Neuroscience letters. 2009; 467(2): 139-43.
  • Singhal Aparna, Nagarajan Rajakumar,
    Kumar Rajesh, Huda Amir, Gupta Rakesh K, Thomas M Albert Magnetic resonance
    T2-relaxometry and 2D L-correlated spectroscopy in patients with minimal
    hepatic encephalopathy. Journal of magnetic resonance imaging : JMRI. 2009; 30(5): 1034-41.
  • Kumar R, Ahdout R, Macey P M, Woo M A,
    Avedissian C, Thompson P M, Harper R M Reduced caudate nuclei volumes in
    patients with congenital central hypoventilation syndrome. Neuroscience. 2009; 163(4): 1373-9.
  • Macey Paul M, Richard Christopher A,
    Kumar Rajesh, Woo Mary A, Ogren Jennifer A, Avedissian Christina, Thompson Paul
    M, Harper Ronald M Hippocampal volume reduction in congenital central
    hypoventilation syndrome. PloS one. 2009; 4(7): e6436.
  • Woo Mary A, Kumar Rajesh, Macey Paul M,
    Fonarow Gregg C, Harper Ronald M Brain injury in autonomic, emotional, and
    cognitive regulatory areas in patients with heart failure. Journal of cardiac failure. 2009; 15(3): 214-23.
  • Kumar Rajesh, Woo Mary A, Birrer
    Bramley V X, Macey Paul M, Fonarow Gregg C, Hamilton Michele A, Harper Ronald M
    Mammillary bodies and fornix fibers are injured in heart failure. Neurobiology of disease. 2009; 33(2): 236-42.
  • Kumar Rajesh, Macey Paul M, Cross
    Rebecca L, Woo Mary A, Yan-Go Frisca L, Harper Ronald M Neural alterations
    associated with anxiety symptoms in obstructive sleep apnea syndrome. Depression and anxiety. 2009; 26(5): 480-91.
  • Kumar Rajesh, Macey Paul M, Woo Mary A,
    Alger Jeffry R, Harper Ronald M Diffusion tensor imaging demonstrates brainstem
    and cerebellar abnormalities in congenital central hypoventilation syndrome. Pediatric research. 2008; 64(3): 275-80.
  • Cross Rebecca L, Kumar Rajesh, Macey
    Paul M, Doering Lynn V, Alger Jeffry R, Yan-Go Frisca L, Harper Ronald M Neural
    alterations and depressive symptoms in obstructive sleep apnea patients. Sleep. 2008; 31(8): 1103-9.
  • Macey Paul M, Kumar Rajesh, Woo Mary A,
    Valladares Edwin M, Yan-Go Frisca L, Harper Ronald M Brain structural changes
    in obstructive sleep apnea. Sleep. 2008; 31(7): 967-77.
  • Woo Mary A, Macey Paul M, Keens Peter
    T, Kumar Rajesh, Fonarow Gregg C, Hamilton Michele A, Harper Ronald M Aberrant
    central nervous system responses to the Valsalva maneuver in heart failure. Congestive heart failure (Greenwich, Conn.). 2008; 13(1): 29-35.
  • Serber Stacy L, Kumar Rajesh, Woo Mary
    A, Macey Paul M, Fonarow Gregg C, Harper Ronald M Cognitive test performance
    and brain pathology. Nursing research. 2008; 57(2): 75-83.
  • Kumar Rajesh, Birrer Bramley V X, Macey
    Paul M, Woo Mary A, Gupta Rakesh K, Yan-Go Frisca L, Harper Ronald M Reduced
    mammillary body volume in patients with obstructive sleep apnea. Neuroscience letters. 2008; 438(3): 330-4.
  • Kumar Rajesh, Gupta Rakesh K,
    Elderkin-Thompson Virginia, Huda Amir, Sayre James, Kirsch Claudia, Guze Barry,
    Han Steve, Thomas M Albert Voxel-based diffusion tensor magnetic resonance
    imaging evaluation of low-grade hepatic encephalopathy. Journal of magnetic resonance imaging : JMRI. 2008; 27(5): 1061-8.
  • Kumar Rajesh, Macey Paul M, Woo Mary A,
    Alger Jeffry R, Harper Ronald M Elevated mean diffusivity in widespread brain
    regions in congenital central hypoventilation syndrome. Journal of magnetic resonance imaging : JMRI. 2006; 24(6): 1252-8.
  • Woo Mary A, Macey Paul M, Keens Peter
    T, Kumar Rajesh, Fonarow Gregg C, Hamilton Michele A, Harper Ronald M
    Functional abnormalities in brain areas that mediate autonomic nervous system
    control in advanced heart failure. Journal of cardiac failure. 2005; 11(6): 437-46.
  • Kumar Rajesh, Macey Paul M, Woo Mary A,
    Alger Jeffry R, Keens Thomas G, Harper Ronald M Neuroanatomic deficits in
    congenital central hypoventilation syndrome. The Journal of comparative neurology. 2005; 487(4): 361-71.
  • Agarwal Atul, Raghav Sanjay, Husain
    Mazhar, Kumar Rajesh, Gupta Rakesh K Epilepsy with focal cerebral
    calcification: role of magnetization transfer MR imaging. Neurology India. 2004; 52(2): 197-9.
  • Chawla S, Kumar S, Garg M, Kumar R, Roy
    R, Gupta R K Metabolite pattern of Cysticercus cellulosae metacestode from
    different predilection sites of swine using proton magnetic resonance
    spectroscopy. Parasite (Paris, France). 2004; 11(2): 161-7.
  • Macey Paul M, Macey Katherine E, Kumar
    Rajesh, Harper Ronald M A method for removal of global effects from fMRI time
    series. NeuroImage. 2004; 22(1): 360-6.
  • Garg Monika, Gupta Rakesh K, Husain
    Mazhar, Chawla Sanjeev, Chawla Jayant, Kumar Rajesh, Rao Sajja B, Misra
    Mithlesh K, Prasad Kashi N Brain abscesses: etiologic categorization with in
    vivo proton MR spectroscopy. Radiology. 2004; 230(2): 519-27.
  • Macey Paul M, Alger Jeffry R, Kumar
    Rajesh, Macey Katherine E, Woo Mary A, Harper Ronald M Global BOLD MRI changes to
    ventilatory challenges in congenital central hypoventilation syndrome. Respiratory physiology & neurobiology. 2003; 139(1): 41-50.
  • Prasad Narayan, Gulati Sanjeev, Gupta
    Rakesh Kumar, Kumar Rajesh, Sharma Kumudini, Sharma Raj Kumar Is reversible
    posterior leukoencephalopathy with severe hypertension completely reversible in
    all patients?. Pediatric nephrology
    (Berlin, Germany)
    .
    2003; 18(11): 1161-6.
  • Kumar Rajesh, Gupta Rakesh K, Rao Sajja
    B, Chawla Sanjeev, Husain Mazhar, Rathore Ram K S Magnetization transfer and T2
    quantitation in normal appearing cortical gray matter and white matter adjacent
    to focal abnormality in patients with traumatic brain injury. Magnetic resonance imaging. 2003; 21(8): 893-9.
  • Pradhan S, Kumar R, Gupta R K
    Intermittent symptoms in neurocysticercosis: could they be epileptic?. Acta neurologica Scandinavica. 2003; 107(4): 260-6.
  • Kumar Rajesh, Gupta Rakesh K, Husain
    Mazhar, Vatsal Davender K, Chawla Sanjeev, Rathore Ram Kishore S, Pradhan Sunil
    Magnetization transfer MR imaging in patients with posttraumatic epilepsy. AJNR. American journal of neuroradiology. 2003; 24(2): 218-24.
  • Gupta Rakesh K, Kumar Rajesh, Chawla
    Sanjeev, Pradhan Sunil Demonstration of scolex within calcified cysticercus
    cyst: its possible role in the pathogenesis of perilesional edema. Epilepsia. 2002; 43(12): 1502-8.
  • Chawla S, Gupta R K, Kumar R, Garg M,
    Pradhan S, Pal L, Husain N, Gupta A, Rathore R K S Demonstration of scolex in
    calcified cysticercus lesion using gradient echo with or without corrected
    phase imaging and its clinical implications. Clinical radiology. 2002; 57(9): 826-34.
  • Garg Monika, Chawla Sanjeev, Prasad
    Kashi N, Roy Raja, Sikora Sadiq S, Kumar Rajesh, Husain Mazhar, Khetrapal C L,
    Gupta Rakesh K Differentiation of hydatid cyst from cysticercus cyst by proton
    MR spectroscopy. NMR in biomedicine. 2002; 15(5): 320-6.
  • Garg Monika, Gupta Rakesh K, Prasad
    Kashi N, Sikora Sadiq S, Pal Lily, Chawla Sanjeev, Kumar Rajesh, Husain Mazhar,
    Saxena Sudhir, Husain Nuzhat, Roy Raja Fertility assessment of hydatid cyst by
    proton MR spectroscopy. The Journal of surgical research. 2002; 106(1): 196-201.
  • Malik G K, Pandey M, Kumar R, Chawla S,
    Rathi B, Gupta R K MR imaging and in vivo proton spectroscopy of the brain in
    neonates with hypoxic ischemic encephalopathy. European journal of radiology. 2002; 43(1): 6-13.
  • Gupta Rakesh K, Husain Mazhar, Vatsal
    Devendra K, Kumar Rajesh, Chawla Sanjeev, Husain Nuzhat Comparative evaluation
    of magnetization transfer MR imaging and in-vivo proton MR spectroscopy in
    brain tuberculomas. Magnetic resonance imaging. 2002; 20(5): 375-81.
  • Kumar R, Gupta R K, Rathore R K S, Rao
    S B, Chawla S, Pradhan S Multiparametric quantitation of the perilesional
    region in patients with healed or healing solitary cysticercus granuloma. NeuroImage. 2002; 15(4): 1015-20.
  • Gupta R K, Vatsal D K, Husain N, Chawla
    S, Prasad K N, Roy R, Kumar R, Jha D, Husain M Differentiation of tuberculous
    from pyogenic brain abscesses with in vivo proton MR spectroscopy and
    magnetization transfer MR imaging. AJNR. American journal of neuroradiology. 2001; 22(8): 1503-9.
  • Gupta R K, Rao S B, Jain R, Pal L,
    Kumar R, Venkatesh S K, Rathore R K Differentiation of calcification from
    chronic hemorrhage with corrected gradient echo phase imaging. Journal of computer assisted tomography. 2001; 25(5): 698-704.
  • Chawla Sanjeev, Gupta Rakesh K, Husain
    Nuzhat, Garg Monika, Kumar Rajesh, Kumar Sunil Prediction of viability of
    porcine neurocysticercosis with proton magnetic resonance spectroscopy:
    correlation with histopathology. Life sciences. 2004; 74(9): 1081-92.
  • Kumar Rajesh, Lee Kwanoo, Macey Paul M,
    Woo Mary A, Harper Ronald M Mammillary body and fornix injury in congenital
    central hypoventilation syndrome. Pediatric research. 2009; 66(4): 429-34.