Research Highlights

Schmidt, N.W., Mishra, A., Lai, G.H., Davis, M., Sanders, L.K., Tran, D., Garcia, A., Tai, K.P., McCray, P.B., Jr., Ouellette, A.J., Selsted, M.E., and Wong, G.C.L., "Criterion for Amino Acid Composition of Defensins and Antimicrobial Peptides Based on Geometry of Membrane Destabilization", J. Am. Chem. Soc., 133(17), pp. 6720-2727, 2011.  Link to Paper

Sun, V.Z., Li, Z., Deming, T.J., and Kamei, D.T., "Intracellular Fates of cell-Penetrating Block Copolypeptide Vesicles", Biomacromolecules, 12:10-13, 2011.  Link to Paper

Hur, S.C., Henderson-MacLennan, N.K., McCabe, E.R., and Di Carlo, D., "Deformability-Based Cell Classification and Enrichment Using Inertial Microfluidics", Lab on a Chip, 11(5):912-920, March 7, 2011. 

Weaver, W.M., Dharmaraja, S., Milisaveljevic, V., and Di Carlo, D., "The Effects of Shear Stress on Isolated Receptor-Ligand Interactions of Staphylococcus Epidermidis and Human Plasma Fibrinogen Using Molecularly Patterned Microfluidics", Lab on a Chip, 11(5):883-889, March 7, 2011.

2010

Zheng, Z., Yin, W., Zara, J.N., Li, W., Kwak, J., Mamid, R., Lee, M., Siu, R.K., Ngo, R., Wang, J., Carpenter, D., Zhang, X., Wu, B., Ting, K., and Soo, C., "The Use of BMP-2 Coupled-Nanosilver-PLGA Composite Grafts to Induce Bone Repair in Grossly Infected Segmental Defects", Biomaterials, 31(35:9293-9300, December 2010.

Gibiansky, M.L., Conrad, J.C., Jin, F., Gordon, V.D., Motto, D.A., Mathewson, M.A., Stopka, W.G., Zelasko, D.C., Shrout, J., and Wong, G.C.L., "Bacteria Use Type IV Pili to Stand, Walk Upright, and Detach from Surfaces", Science, 330:197, 2010.  Link to paper

Poulos, J.L., Jeon, T.-J., Schmidt, J.J., "Automatable Production of Shippable Bilayer Chips by Pin Tool Deposition for an Ion Channel Measurement Platform", Biotechnology Journal, 5(5): 511-514, 2010

Deming, T.J., "Noodle Gels for Cells", Nature Materials, 9:535-536, 2010

Lee, W., Amini, H., Stone, H.A., and Di Carlo, D., "Dynamic Self-Assembly and Control of Microfluidic Particle Crystals", The Proceedings of the National Academy of Sciences, 107(52):22413-22418, December 28, 2010.

Professor Dino Di Carlo's Group have developed a miniature flow cytometer that can analyze up to one million blood cells per second.

Article featured in Highlights in Chemical Biology

Hur SC, Tse HTK, Di Carlo D. Sheathless inertial cell ordering for extreme throughput flow cytometry. Lab on a Chip 2010; 10:274-280. (Selected for cover page article)  Link to Journal Article.

Holowka, E.P., and Deming, T.J., "Synthesis and Crosslinking of L-DOPA Containing Polypeptide Vesicles," Macromolecular Bioscience., Feb 2010.  Read Article

Wong, D.Y., Griffin, D.R., Reeds, J., and Kasko, A.M., "Photodegradable Hydrogels to Generate Positive and Negative Features over Multiple Length Scales," Macromolecules, February 24, 2010 (published on web:  DOI: 10.1021/ma9023679).  Read Article

Lee, M., Siu, R.K., Ting, K., and Wu, B.M., "Effect of Nell-1 Delivery on Chondrocyte Proliferation and Cartilaginuos Extracellular Matrix Deposition," Tissue Eng Part A. 2010.  Read Article

2009

 

Schmidt, N., Mishra, A., Lai, G.H., and Wong, G.C., "Arginine-Rich Cell-Penetrating Peptides," FEBS Lett, November 2009.  Read Article

Lee, M., Li, W., Siu, R.K., Whang, J., Zhang, X., Soo, C., Ting, K., Wu, B.M., "Biomimetic Apatite-Coated Alginate/Chitosan Microparticles as Osteogenic Protein Carriers," Biomaterials, 30(30): 6094-6101, October 2009. 
Read Article

Wei, F., Liao, W., Zhang, L., Arellano-Garcia, M., Hu, Shen, Wong, D.T., and Ho, C.M., “Electrochemical Sensor for Oral Cancer Detection with Multiplex Salivary Biomarkers”, Clinical Cancer Research, vol. 15, pp. OF1 – OF7, July 2009.  Link to Journal Article

Mashayekhi, F., Meyer, A.S., Shiigi, S.A., Nguyen, V., and Kamei, D.T., "Concentration of Mammalian Genomic DNA Using Two-Phase Aqueous Micellar Systems," Biotechnology and Bioengineering, 102(6):1613-1623, April 2009.  Read Article

Poulos, J., Nelson, W., Jeon, T.J., Kim, C., and Schmidt, J.J., "Electrowetting on Dielectric-Based Microfluidics for Integrated Lipid Bilayer Formation and Measurement," Applied Physics Letter, 95, 013706, 2009.  Read Article

Franco, M.L., King, C.-H., Culjat, M.O., Lewis, C.E., Bisley, J.W., Holmes, E.C., Grundfest, W.S., and Dutson, E.P., "An Integrated Pneumatic Tactile Feedback Actuator Array for Robotic Surgery," The International Journal of Medical Robotics and Computer Assisted Surgery, 5(1): 13-19, 2009.  Read Article

2008

Scientists, Professors Tim Deming and Thomas Mason, produce nanoscale droplets with cancer-fighting implications

Article featured in UCLA Newsroom

"Nanoscale Double Emulsions Stabilized by Single Component Block Copolypeptides" Hanson, J.A.; Chang, C.; Graves, S.; Li, Z.; Mason, T.G.; and Deming, T.J., Nature, 2008, 455, 85-88.
Link to Journal Article

Professor Daniel Kamei's group is doing research on Intracellular Drug Trafficking Applications in Cancer Drug Delivery

Article from Winter 2008 UCLA Engineer Issue No. 21

Full Issue from Winter 2008 UCLA Engineer Issue

2007

The research labs of Professors Timothy Deming and Daniel Kamei demonstrated in vitro that their novel polymeric vesicles can transport dye-labeled dextran into both epithelial and endothelial cells without being toxic. 

“Polyarginine Segments in Block Copolypeptides Drive Both Vesicular Assembly and Intracellular Delivery” Holowka, E. P.; Sun, V. Z.; Kamei, D. T.; Deming, T. J., Nature Materials, 2007, 6, 52–57.  Link to Journal Article