M. Albert Thomas Phd


Department of Radiology, Psychiatry
1417A Peter V. Ueberroth Building
10945 Le Conte Ave., Los Angeles, CA 90095



  • MS, American College Madurai University, 1978
  • PhD, Indian Institute of Science, 1984


Awards and Positions

  • Cover Article of Magnetic Resonance in Medicine, “Echo planar correlated spectroscopic imaging: Implementation and pilot evaluation in human calf in vivo,” 2010
  • Young Investigator Award, Whitaker Foundation’s Biomedical Engineering Grants, 1991

Research Interests

  • Physics of MR imaging and spectroscopy
  • Developments of new MR spectroscopic imaging (MRSI)
  •  Evaluation of MRSI techniques in healthy tissues and in
    different pathologies


Development of Multi-dimensional MR Spectroscopic Techniques and Evaluation in Different Diseases
To implement 2-, 3- and 4- dimensional MRS techniques, and to evaluate them in human tissues

Two-Dimensional MR Spectroscopic Characterization of HE
To correlate the metabolite ratios using the 2D L-COSY sequence on a 1.5T MRI scanner with neuron- psychological test battery, and MRI of basal ganglia.

Biochemical and Anatomical Correlates of Human Breast Cancer In Vivo
To correlate the anatomical changes with that of the bio- chemicals (metabolites and lipids) in breast cancer and healthy women.

A Novel Assay of Citrate, Choline, and Spermine in Prostate Cancer In Vivo
To detect the biochemical changes in malignant and benign prostate cancer compared to healthy men.

Neurobiological & Behavioral Substrates of Mood Disorders
To record the anatomical and biochemical changes in geriatric depression.

MR & Neuroendocrine Analysis of Bipolar Disorder and Alcohol Abuse Comorbidity
To record the metabolite levels in bipolar & healthy controls

Implementation and Evaluation of Cardiac MRSI in Humans
To implement and evaluate cardiac proton MRS

Recent Papers


  1. McClure T.D., Margolis D.J., Reiter R.E., Sayre J.W., Thomas M.A., Nagarajan R., Gulati M., Raman S.S. “Use of MR Imaging to Determine Preservation of the Neurovascular Bundles at Robotic-assisted Laparoscopic Prostatectomy,” Radiology. 2012 Jan 24. (Epub ahead of print)
  2. Nagarajan R., Margolis D., Raman S., Sheng K., King C., Reiter R., Thomas M.A., “Correlation of Gleason scores with diffusion-weighted imaging findings of prostate cancer,” Avd Urol. 2012;2012:374805. Epub 2011 Dec 15.
  3. Furuyama J.K., Wilson N.E., Thomas M.A., “Spectroscopic imaging using concentrically circular echo-planar trajectories in vivo,” Magn Reson Med. 2011 Oct 17. (Epub ahead of print)
  4. Verma G., Lipnick S., Ramadan S., Nagarajan R., Thomas M.A., “Implementation of multi-echo-based correlated spectroscopic imaging and pilot findings in human brain and calf muscle,” J Magn Reson Imaging. 2011 Aug;34(2):262-9.
  5. Nagarajan R., Margolis D., McClure T., Raman S., Thomas M.A., “Role of endorectal magnetic resonance spectroscopic imaging in two different Gleason scores in prostate cancer,” Med Princ Pract. 2011;20(5):444-8. Epub 2011 Jul 11.
  6. Sarma M.K., Huda A., Nagarajan R., Hinkin C.H., Wilson N., Gupta R.K., Frias-Martinez E., Sayre J., Guze B., Han S.H., Thomas M.A., “Multi-dimensional MR spectroscopy: towards a better understanding of hepatic encephalopathy,” Metab Brain Dis. 2011 Sep;26(3):173-84. Epub 2011 Jun 23.
  7. Nagarajan R., Ramadan S., Thomas M.A., “Detection of Amide and Aromatic Proton Resonances of Human Brain Metabolites Using Localized Correlated Spectroscopy Combined with Two Different Water Suppression Schemes,” Magn Reson Insights. 2010 Jun 15;2010(4):1-9.
  8. Lipnick S. Liu X., Sayre J., Bassett L.W., Debruhl N., Thomas M.A., “Combined DCE-MRI and single-voxel 2D MRS for differentiation between benign and malignant breast lesions,” NMR Biomed. 2010 Oct;23(8):922-30.
  9. Singhal A., Nagarajan R., Hinkin C.H., Kumar R., Sayre J., Elderkin-Thompson V., Huda A., Gupta R.K., Han S.H., Thomas M.A., “Two-dimensional MR spectroscopy of minimal hepatic encephalopathy and neuropsychological correlates in vivo,” J Mang Reson Imaging. 2010 Jul;32(1):35-43.
  10. Lipnick S., Verma G., Ramadan S., Furuyama J., Thomas M.A., “Echo planar correlated spectroscopic imaging: implementation and pilot evaluation in human calf in vivo,” Magn Reson Med. 2010 Oct;64(4):947-56.